The COVID-19 pandemic has been challenging the world for many months, drawing the public’s attention to the field of epidemiology. Governments around the globe urgently call on the scientific community to provide guidelines for the treatment and prevention of coronavirus infections. Immunity protection (natu-ral or man-made) is at the epicentre of state policies and public discussions. It is less known that the epi-demiological discourse had been used beyond natural sciences in the domain of philosophy and social research. This paper introduces the concept of social immunology developed by Italian philosopher Rob-erto Esposito at the turn of the 20th century as part of the discussion of the notion of biopolitics. I re-read one of my previous research projects through the lens of Esposito’s theory to show the potential of his theoretical constructs in studies on migration and integration.